Since the introduction into the market of HPMCP (hypromellose phthalate) in 1971 as alternative cellulose derivative for enteric coating it has been demonstrated to be an effective and safe material by many researchers.
HPMCP is widely used as an enteric coating agent by the pharmaceutical industry. HPMCP has been admitted into the U.S. National Formulary (USP/NF), European Pharmacopoeia (EP), and Japanese Pharmacopoeia (JP).
The chemical structure of HPMCP is a monophthalic acid ester of hypromellose (hydroxypropyl methylcellulose), and the threshold pH value for rapid disintegration of HPMCP can be controlled by varying the phthalyl content. Two types of HPMCP with different in pH-solubilities, HP-55 and HP-50, are available. Moreover, HP-55S, a special type of HP-55, which is distinguished by its higher molecular weight, greater film strength and higher acid resistance properties, has also been introduced. A suitable grade of HPMCP for a particular purpose should be selected in accordance with each preparation.
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