Metolose®

Shin-Etsu Chemical Co., Ltd. began to produce water soluble cellulose ethers in 1962, with the trade name METOLOSE®.

 

METOLOSE® can be used as a binder for solid dosage forms such as tablets and granules. It also provides a variety of functions such as water retention, thickening, protective colloid, surface activity, sustained release, etc. It is also regarded as a non-digestive fiber. METOLOSE® consists of Methylcellulose (Methylcellulose USP) and three substitution types of Hydroxypropylmethylcellulose (Hypromellose USP) each available in several grades differing in viscosity.

 

Characteristics of METOLOSE®

Odorless and tasteless
METOLOSE® is a fibrous or granular powder, white to slightly off-white in color, and practically odorless and tasteless.

Low ash content
As METOLOSE® is a nonionic organic compound; it can be completely combusted under appropriate burning conditions. It can also be effectively purified by washing, so its ash content is very low.

Water-soluble thickener
Although METOLOSE® is insoluble in hot water, it is soluble in cold water, giving a transparent viscous solution.

Thermal gelation
An aqueous solution of METOLOSE® gels or forms a precipitate when heated to a certain temperature, but it reverts to the clear solution state on subsequent cooling. The thermal gelation/precipitation temperature depends onthe substitution type, concentration, and heating rate.

Resistant to salting out
METOLOSE® is non-ionic and is not a polyelectrolyte. An aqueous solution of METOLOSE® is relatively stable in the presence of inorganic salts or organic electrolytes. However, when the concentration of electrolyte exceeds a certain limit, gelation or precipitation may occur.

Stable over a wide pH range
The viscosity of METOLOSE® solution is hardly affected by acid or alkali, and is stable at pH 3-11. However, the viscosity tends to decrease during prolonged storage of a solution under acidic or alkaline conditions.

Soluble in some organic solvents
Owning to the presence of relatively hydrophobic met Methoxy hydroxypropoxy groups, METOLOSE® is soluble in some organic solvents and also in water-organic solvent mixtures.

Surface active
An aqueous solution of METOLOSE® has a high surface activity and functions as a protective colloid agent and a stabilizer for emulsions, suspensions, or foam.

Film forming
METOLOSE® provides strong, flexible and transparent films with a good barrier property against oils.

 

METOLOSE® Applications


PHARMACOAT® and METOLOSE® can also be used as a binder for granulation. The fine particle size (average 50-70 μm) allows good mixture with the vehicle (lactose/cornstarch) and PHARMACOAT® and METOLOSE® is effective for fluidized bed granulation and high shear mixer granulation (dry-blend).


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