Technical Sheets

Our research and development are extensively working with our products to generate data. The technical sheets contain information of our polymer which will help you enable to develop your products. If you have a particular application which we have not included then please e-mail us at Contact@SE-PFMD.com and our team will be happy to help you.
PHARMACOAT®
An organic coating method with Pharmacoat, with mixed solvent of high content of ethanol and water

Film coated tablets containing water sensitive API often use a coating solvent consisting of a high content of organic solvents such as ethanol in water. In this study, a method for solution preparation with Pharmacoat in mixed solvents of high ethanol content in water, and coating technique are introduced.

Application of Pharmacoat as a carrier in solid dispersion

"Solid dispersion" is a technique used to enhance the bioavailability of poorly-soluble drugs in increase their solubility. In this study, as solid dispersion preparation method using Pharmacoat as a carrier is introduced, along with its application to solid dosage forms.

Colour coating with Pharmacoat

Pharmacoat is widely used for film coating and this technical sheet includes typical colour coating formulations.

Effect of moisture content on the mechanical properties of cast HPMC films

The mechanical properties of coating films are important characteristics because they affect various properties of film-coated dosage forms.

Effect of plasticizers and other additives on the mechanical properties of cast hypromellose films

In this study, the effect of plasticizers, sugars and lower viscosity polymers on the mechanical properties of cast hypromellose films was investigated using various grades of Pharmacoat.

Filtration of Pharmacoat solutions

Filtration is a common technique to eliminate black specs. This technical sheet shows the filtration resistance of several formulations using Pharmacoat.

Growth of microorganisms in aqueous solution of Pharmacoat

Pharmacoat is widely used in film coating of solid dosage forms, were the adoption of the aqueous coating technique has become common place. In applying an aqueous film coating, it is necessary to control the microbiological content of the coating solution, especially when prepare in advance and allowed to stand for an extended period of time prior to use.

Solubility of Pharmacoat 606 in alcohol-water mixtures

The solubility of Pharmacoat 606 in the mixture of methanol/water, ethanol/water and isopropyl alcohol (IPA)/water was investigated.

Stability of Pharmacoat solution in sterilization

Heating is a common sterilization method for aqueous solution of Hypromellose. It has been recognized that 120 degree for 30 minutes is sufficient for the sterilization in most cases. This type of sterilization is typically used in the production of eye drops with polymer concentration below 1%.

Timed-release coating with Pharmacoat and Shin-Etsu AQOAT® for taste-masking effect

The time release of API after a lag time for 5-10 minutes after administration is a feature of the dissolution behavior of sugar coating, and such coating is a suitable method for taste masking.

METOLOSE®
Adjusting viscosity by blending two grades of Metolose

This technical sheet demonstrates how two different viscosity grades of Metolose can be blended together to obtain material with a desired viscosity.

Metolose SM-4 for pellet film coating

Film coating sometimes is used to protect coated pellets or to prevent chemical interactions between active ingredients and excipients, however regular film coating agents such as PHARMACOAT® are difficult to use for pellet coating due to agglomeration during the fluid bed coating process. METOLOSE® SM-4, an extremely low viscosity methycellulose is useful for aqueous film coating of pellets since it is less sticky and water soluble.

Solubility of HPMC and MC in organic solvents

Hypromellose and Methycellulose is insoluble in organic solvents and in this study shows the solubility of HPMC and MC is different organic solvents.

 

Taste masking for fine granules by Metolose and an acrylic polymer

Taste masking is a common issue in formulation development. In this study, as aqueous coating using Metolose SM-4 and acrylic polymer was applied to taste masking.

METOLOSE® SR
A study on the robustness of the wet granulation process to prepare Metformin HCL extended-release matrix tablet using Metolose 90SH-15000SR

 The robustness of the wet granulation process was investigated in preparing Metformin HCL extended release matrix tablets using Metolose 90SH 15000SR. To observe the relationship between the processing parameters and tablet performance, an orthogonal-array design was applied to the evaluation.

 

Bilayer tablets using L-HPC and Metolose SR

The preparation of bilyaer tablets using L-HPC and Metolose SR was studied. The best grade of L-HPC was selected using preliminary study to reduce the anti lamination and then applied in a rotary tablet press.  

Comparison between direct compression and wet granulation in hydrophilic matrix tablet using Metolose SR

The purpose of this study was to compare direct compression and wet granulation for preparation of hydrophilic matrix tablets using Metolose SR. Tablet productivity using a s rotary tablet press was investigated, specifically for tablet weight deviation.

Formulation Example: Lithium Carbonate Extended-Release tablet using Metolose SR

Lithium Carbonate was incorporated into the formulation to demonstrate that Metolose SR can be used for an extended release.

 

Solvent selection in wet granulation for hydrophilic matrix tablets using Metolose SR

An aqueous alcoholic solution is one of the suitable solvents to prepare hydrophilic matrix tablets by wet granulation. In this study, the effect of ethanol-water ratio and granulation time was examined.

Sustained release of Naproxen using Metolose SR

It is difficult to control the release if some active ingredients though dry blending with a polymer, followed by direct compression. Naproxen is an example drug that showed an initial release when tablets were made via this method.

HPMCP
Aqueous Dispersion Coating with Shin-Etsu Aqoat

Ammonia-Neutralized method part 1: Solution and film properties.

Enteric coating of hard gelatin capsules using HPMCP

The technical sheet gives an example of enteric coating of hard gelatin capsules using HPMCP.

Film solubility of HPMCP in various buffers

Film solubility (in terms of disintegration time of films specimens) of HPMCP was investigated.

HPMCP- Typical coating conditions for tablets

Examples of formulations using HPMCP in different solvent systems and their typical coating conditions for a batch size of 5kg.

HPMCP-Typical coating conditions for granules (1)

Examples of formulations using HPMCP in different solvent systems and their typical coating conditions for a batch size of 5kg.

HPMCP-Typical coating conditions for granules (2)

Examples of formulations using HPMCP in different solvent systems and their typical coating conditions for a batch size of 1.5kg.

Hydrolysis of HPMCP in ethanol-water solution

Stability of the ethanol-water coating solution of Hypromellose Phthalate (HP-55 & HP-50) was studied.

Molecular weight of HPMCP

Molecular weight of HPMCP is related to the viscosity of the polymer. This technical sheet includes the test method and results of Mw of all HPMCP grades.

 

Residual solvent in ethanol/water HP-55 tablet coating

The ethanol/water system is commonly used for HPMCP tablet coating. Ethanol is categorized as a class 3 solvent in the ICH guidelines and its regulated upper limit is 5,000ppm. The effect of operating condition on the level of residual ethanol has been studied.

Shin-Etsu AQOAT®
Aqueous Dispersion Coating Using Shin-Etsu Aqoat

Preparation of coating dispersion

Aqueous Dispersion Coating Using Shin-Etsu Aqoat

Coating parameters of a tablet batch size 5-100kg

Aqueous Dispersion Coating Using Shin-Etsu Aqoat

Using a small tabletop coating machine we coated tablet batch size of 300g

Enteric Coating with Shin-Etsu Aqoat (HPMCAS) by Using Water-Ethanol Solution

HPMCAS can be used for solvent based coating. One of the advantages is using ethanol-water mixtures greater amount of water can be added to the formulation compared to an HPMCP.

Examples of Aqueous Dispersion Coating Using Shin-Etsu Aqoat

Coating parameters granules batch size 1.5kg

Minimum Film Formation Temperature of Shin-Etsu Aqoat

It is important to know minimum film Formation temperature of polymers for characterization of the coating formulations. We investigated minimum film Formation temperature of Shin-Etsu Aqoat (HPMCAS).

Molecular Weight of Shin-Etsu Aqoat (HPMCAS)

Please find the method and results of the molecular weight of Shin-Etsu Aqoat.

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Seminars

Shin-Etsu presents 3rd Technical Seminar on Solubility enhancement from the 13-14th June 2017 at University of Bradford, UK.
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